Publications of Ana J. Garcia-Saez

Bleicken, S.; Hantusch, A.; Das, K. K.; Frickey, T.; Garcia-Saez, A. J.: Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. Nature Communications 8, 73 (2017)

Das, K. K.; Shalaby, R.; García-Sáez, A. J.: Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes. ACS Chemical Biology 12 (4), pp. 989 - 1000 (2017)

Ros, U.; Peña-Blanco, A.; Hänggi, K.; Kunzendorf, U.; Krautwald, S.; Wong, W. W.-L.; García-Sáez, A. J.: Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium. Cell Reports 19, pp. 175 - 187 (2017)

Cosentino, K.; García-Sáez, A. J.: Bax and Bak Pores: Are We Closing the Circle? Trends in Cell Biology 27 (4), pp. 266 - 275 (2017)

Fernández-Marrero, Y.; Bleicken, S.; Das, K. K.; Bachmann, D.; Kaufmann, T.; Garcia-Saez, A. J.: The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID. The FEBS Journal 284 (5), pp. 711 - 724 (2017)

Mesa-Galloso, H.; Delgado-Magnero, K. H.; Cabezas, S.; López-Castilla, A.; Hernández-González, J. E.; Pedrera, L.; Alvarez, C.; Peter Tieleman, D.; García-Sáez, A. J.; Lanio, M. E. et al.; Ros, U.; Valiente, P. A.: Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity. Protein Science 26 (3), pp. 550 - 565 (2017)

Unsay, J. D.; Cosentino, K.; Sporbeck, K.; García-Sáez, A. J.: Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. Biochimica et Biophysica Acta: BBA 1859 (1), pp. 17 - 27 (2017)

Fischer, A. W.; Bordignon, E.; Bleicken, S.; García-Sáez, A. J.; Jeschke, G.; Meiler, J.: Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAX. Journal of Structural Biology 195 (1), pp. 62 - 71 (2016)

Navarro, G.; Cordomí, A.; Zelman-Femiak, M.; Brugarolas, M.; Moreno, E.; Aguinaga, D.; Perez-Benito, L.; Cortés, A.; Casadó, V.; Mallol, J. et al.; Canela, E. I.; Lluís, C.; Pardo, L.; García-Sáez, A. J.; McCormick, P. J.; Franco, R.: Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G_i and G_s. BMC Biology 14, 26 (2016)

García-Sáez, A. J.; Villunger, A.: MOMP in the absence of BH3-only proteins. Genes and Development 30 (8), pp. 878 - 880 (2016)

Cosentino, K.; Ros, U.; Garcia-Saez, A. J.: Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes. Biochimica et Biophysica Acta: BBA 1858 (3), pp. 457 - 466 (2016)

Salvador-Gallego, R.; Mund, M.; Cosentino, K.; Schneider, J.; Unsay, J.; Schraermeyer, U.; Engelhardt, J.; Ries, J.; García-Sáez, A. J.: Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. The EMBO Journal 35 (4), pp. 389 - 401 (2016)

Bleicken, S.; Hofhaus, G.; Ugarte-Uribe, B.; Schröder, R.; García-Sáez, A. J.: cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities. Cell Death and Disease 7, e2121 (2016)

Sudji, I. R.; Subburaj, Y.; Frenkel, N.; García-Sáez, A. J.; Wink, M.: Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol. Molecules 20 (11), pp. 20146 - 20160 (2015)

Ros, U.; Rodríguez-Vera, W.; Pedrera, L.; Valiente, P. A.; Cabezas, S.; Lanio, M. E.; García-Sáez, A. J.; Alvarez, C.: Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus. Biochimie 116, pp. 70 - 78 (2015)

Subburaj, Y.; Cosentino, K.; Axmann, M.; Pedrueza-Villalmanzo, E.; Hermann, E.; Bleicken, S.; Spatz, J.; García-Sáez, A. J.: Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species. Nature Communications 6, 8042 (2015)

Unsay, J. D.; Cosentino, K.; García-Sáez, A. J.: Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers. Journal of Visualized Experiments (101), e52867 (2015)

Landeta, O.; Landajuela, A.; Garcia Saez, A. J.; Basañez, G.: Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK. Journal of Biological Chemistry 290 (27), pp. 17004 - 17019 (2015)

Ros, U.; García-Sáez, A. J.: More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes. The Journal of Membrane Biology 248 (3), pp. 545 - 561 (2015)

Müller, H.-M.; Steringer, J. P.; Wegehingel, S.; Bleicken, S.; Münster, M.; Dimou, E.; Unger, S.; Weidmann, G.; Andreas, H.; García-Sáez, A. J. et al.; Wild, K.; Sinning, I.; Nickel, W.: Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces. Journal of Biological Chemistry 290 (14), pp. 8925 - 8937 (2015)