Protein Therapeutics

Protein Therapeutics

Welcome to the homepage of the Protein Therapeutics Group!
My team, comprising mainly chemists, is a part of the Department of Synthesis of Macromolecules at the Max Planck Institute for Polymer Research in Mainz, Germany. Our research is inspired by biomolecular processes that occur in the complex environment in living systems and biomacromolecular architectures which give rise to distinct functions in Nature. Specifically, we seek to derive innovative synthetic strategiess by merging molecular biology and chemistry to create structurally complex and stimuli-responsive multicomponent proteins that address both the cellular and physicochemical space of the TME. We are particularly interested in biopolymers with catalytic functions to achieve a sustainable effect in the TME.

Research Highlights and News

Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments
We exploit dynamic covalent chemistries with complementary features that allow us to tune linker stability in biological media and programmed release in the tumor microenvironment.
Contemporary Approaches for Site‐selective Dual Functionalization of Proteins
Lujuan put together a comprehensive review on the current status and potential of dual modification of protein. Read this review and our take on where the field could be heading

Functional Protein–(Bio)Polymer Assemblies
Our book chapter in Supramolecular Protein Chemistry: Assembly, Architecture and Application edited by Peter Crowley
"An experiment is a question which science poses to Nature, and a measurement is the recording of Nature’s answer."
                                                                                                                    - Max Planck, 1858-1947

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