Jiaxu, Christopher and coauthors show that well-defined, hydrogen-terminated molecular nanographenes serve as chemically confined precursors for high-pressure, high-temperature synthesis of ultrasmall (3–4 nm), monodisperse and highly crystalline molecular nanodiamonds (m-NDs) with only a single sp² surface reconstruction and produced on a milligram scale, establish a scalable and modular route to high-quality molecular and fluorescent nanodiamonds and offer a general design principle for tailored quantum materials and nanoscale devices.

Qi and coauthors discuss recent advances in ND-enabled radical sensing in living systems, address key challenges including measurement artefacts, ND heterogeneity, surface- and environment-dependent signal modulation, and the limited chemical specificity of T₁-based readouts, and outline future opportunities in complex biological models. 

Kaiqi and coauthros reveal nanoscale subcellular thermal trigger for immune activation is independent of the canonical heat-shock pathway by introducing a quantum-enabled strategy for probing and programming cellular thermodynamics at the nanoscale.

Qi, Berlind, and coauthors in situ evaluate the comproportionation reaction in a nanoscale thin layer of eumelanin by detecting and quantifying semiquinone radicals through nanodiamond quantum sensor, for the first time.