Wei and coauthors present a quantum-enabled, magnetically modulated fluorescent nanodiamond LFA (FND-LFA) for amplification-free RNA detection through nucleic acid hybridization.The platform achieves a 10 fM detection limit and a linear range of 10 fM to 10 pM for SARS-CoV-2 RNA, together with a 100 fM detection limit for cancer-associated miRNAs. This strategy offers a compact and generalizable route for sensitive, amplification-free RNA diagnostics.

Qi and coauthors discuss recent advances in ND-enabled radical sensing in living systems, address key challenges including measurement artefacts, ND heterogeneity, surface- and environment-dependent signal modulation, and the limited chemical specificity of T₁-based readouts, and outline future opportunities in complex biological models. 

Jiaxu, Christopher and coauthors show that well-defined, hydrogen-terminated molecular nanographenes serve as chemically confined precursors for high-pressure, high-temperature synthesis of ultrasmall (3–4 nm), monodisperse and highly crystalline molecular nanodiamonds (m-NDs) with only a single sp² surface reconstruction and produced on a milligram scale, establish a scalable and modular route to high-quality molecular and fluorescent nanodiamonds and offer a general design principle for tailored quantum materials and nanoscale devices.

Qi, Berlind, and coauthors in situ evaluate the comproportionation reaction in a nanoscale thin layer of eumelanin by detecting and quantifying semiquinone radicals through nanodiamond quantum sensor, for the first time.

Kaiqi and coauthros reveal nanoscale subcellular thermal trigger for immune activation is independent of the canonical heat-shock pathway by introducing a quantum-enabled strategy for probing and programming cellular thermodynamics at the nanoscale.