Publications of Ana J. García-Sáez

Ros, U.; Martinez-Osorio, V.; Valiente, P. A.; Abdelwahab, Y.; Gojkovic, M.; Shalaby, R.; Zanna, S.; Saggau, J.; Wachsmuth, L.; Nemade, H. N. et al.; Zoeller, J.; Lottermoser, H.; Chen, Y.-G.; Ibrahim, M.; Kelepouras, K.; Vasilikos, L.; Bedoya, P.; Espiritu, R. A.; Müller, S.; Altmannova, V.; Tieleman, D. P.; Weir, J.; Langer, J. D.; Adam, M.; Walczak, H.; Wong, W. W.-L.; Liccardi, G.; Mollenhauer, M.; Pasparakis, M.; Peltzer, N.; García-Sáez, A. J.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular Cell 85 (2025)

Zaghbani, S.; Faber, L.; Garcia Saez, A. J.: Convolutional Neural Network approach to classify mitochondrial morphologies. Computational Biology and Chemistry 118, 108477 (2025)

Roeck, B. F.; Lotfipour Nasudivar, S.; Vorndran, M. R. H.; Schueller, L.; Yapici, F. I.; Rübsam, M.; von Karstedt, S.; Niessen, C. M.; Garcia-Saez, A. J.: Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nature Communications 16, 2951 (2025)

Zaghbani, S.; Pranti, R. K.; Faber, L.; Garcia-Saez, A. J.: MitoSkel: AI tool for semantic segmentation and quantification of mitochondria from light microscopy images. Biomedical Signal Processing and Control 106, 107762 (2025)

Smarduch, S.; Moreno-Velasquez, S. D.; Ilic, D.; Dadsena, S.; Morant, R.; Ciprinidis, A.; Pereira, G.; Binder, M.; García-Sáez, A. J.; Acebrón, S. P.: A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. The EMBO Journal (2025)

Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death and Disease 16, 40 (2025)

Etxebeste-Mitxeltorena, M.; Flores-Romero, H.; Ramos-Inza, S.; Masiá, E.; Nenchova, M.; Montesinos, J.; Martinez-Gonzalez, L.; Porras, G.; Orzáez, M.; Vicent, M. J. et al.; Gil, C.; Area-Gomez, E.; Garcia-Saez, A. J.; Martinez, A.: Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model. Journal of Medicinal Chemistry 68 (2), pp. 1179 - 1194 (2025)

Lotfipour Nasudivar, S.; Pedrera, L.; García-Sáez, A. J.: Iron-Induced Lipid Oxidation Alters Membrane Mechanics Favoring Permeabilization. Langmuir 40 (47), pp. 2561 - 2568 (2024)

Schmitt, L.; Krings, K. S.; Wolsing, A.; Buque, X.; Zimmermann, M.; Flores-Romero, H.; Lenz, T.; Lechtenberg, I.; Peter, C.; Stork, B. et al.; Teusch, N.; Proksch, P.; Stühler, K.; García-Sáez, A. J.; Reichert, A. S.; Aspichueta, P.; Bhatia, S.; Wesselborg, S.: Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells. Cell Communication and Signaling 22, 541 (2024)

Berndt, C.; Alborzinia, H.; Amen, V. S.; Ayton, S.; Barayeu, U.; Bartelt, A.; Bayir, H.; Bebber, C. M.; Birsoy, K.; Böttcher, J. P. et al.; Brabletz, S.; Brabletz, T.; Brown, A. R.; Brüne, B.; Bulli, G.; Bruneau, A.; Chen, Q.; DeNicola, G. M.; Dick, T. P.; Distéfano, A.; Dixon, S. J.; Engler, J. B.; Esser-von Bieren, J.; Fedorova, M.; Friedmann Angeli, J. P.; Friese, M. A.; Fuhrmann, D. C.; García-Sáez, A. J.; Garbowicz, K.; Götz, M.; Gu, W.; Hammerich, L.; Hassannia, B.; Jiang, X.; Jeridi, A.; Kang, Y. P.; Kagan, V. E.; Konrad, D. B.; Kotschi, S.; Lei, P.; Le Tertre, M.; Lev, S.; Liang, D.; Linkermann, A.; Lohr, C.; Lorenz, S.; Luedde, T.; Methner, A.; Michalke, B.; Milton, A. V.; Min, J.; Mishima, E.; Müller, S.; Motohashi, H.; Muckenthaler, M. U.; Murakami, S.; Olzmann, J. A.; Pagnussat, G.; Pan, Z.; Papagiannakopoulos, T.; Pedrera Puentes, L.; Pratt, D. A.; Proneth, B.; Ramsauer, L.; Rodriguez, R.; Saito, Y.; Schmidt, F.; Schmitt, C.; Schulze, A.; Schwab, A.; Schwantes, A.; Soula, M.; Spitzlberger, B.; Stockwell, B. R.; Thewes, L.; Thorn-Seshold, O.; Toyokuni, S.; Tonnus, W.; Trumpp, A.; Vandenabeele, P.; Vanden Berghe, T.; Venkataramani, V.; Vogel, F. C. E.; von Karstedt, S.; Wang, F.; Westermann, F.; Wientjens, C.; Wilhelm, C.; Wölk, M.; Wu, K.; Yang, X.; Yu, F.; Zou, Y.; Conrad, M.: Ferroptosis in health and disease. Redox Biology: an official journal of the Society for Free Radical Biology and Medicine 75, 103211 (2024)

Dai, E.; Chen, X.; Linkermann, A.; Jiang, X.; Kang, R.; Kagan, V. E.; Bayir, H.; Yang, W. S.; Garcia-Saez, A. J.; Ioannou, M. S. et al.; Janowitz, T.; Ran, Q.; Gu, W.; Gan, B.; Krysko, D. V.; Zhu, X.; Wang, J.; Krautwald, S.; Toyokuni, S.; Xie, Y.; Greten, F. R.; Yi, Q.; Schick, J.; Liu, J.; Gabrilovich, D. I.; Liu, J.; Zeh, H. J.; Zhang, D. D.; Yang, M.; Iovanna, J.; Kopf, M.; Adolph, T. E.; Chi, J.-T.; Li, C.; Ichijo, H.; Karin, M.; Sankaran, V. G.; Zou, W.; Galluzzi, L.; Bush, A. I.; Li, B.; Melino, G.; Baehrecke, E. H.; Lotze, M. T.; Klionsky, D. J.; Stockwell, B. R.; Kroemer, G.; Tang, D.: A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology 26 (9), pp. 1447 - 1457 (2024)

Dadsena, S.; Cuevas Arenas, R.; Vieira, G.; Brodesser, S.; Melo, M. N.; García-Sáez, A. J.: Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature Communications 15, 4700 (2024)

Froehlich, T.; Jenner, A.; Cavarischia-Rega, C.; Fagbadebo, F. O.; Lurz, Y.; Frecot, D. I.; Kaiser, P. D.; Nueske, S.; Scholz, A. M.; Schäffer, E. et al.; Garcia Saez, A. J.; Macek, B.; Rothbauer, U.: Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life science alliance 7 (8), e202402608 (2024)

García-Sáez, A. J.; Domingos, A. I.; Gutkind, J. S.; Mattoo, S.; Du, P.: Many paths lead to immunology. Cell 187 (9), pp. 2117 - 2119 (2024)

Schmitt, L.; Lechtenberg, I.; Drießen, D.; Flores-Romero, H.; Skowron, M. A.; Sekeres, M.; Hoppe, J.; Krings, K. S.; Llewellyn, T. R.; Peter, C. et al.; Stork, B.; Qin, N.; Bhatia, S.; Nettersheim, D.; Fritz, G.; García-Sáez, A. J.; Müller, T. J. J.; Wesselborg, S.: Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Cell Death Discovery 10, 125 (2024)

Freitas, F. P.; Alborzinia, H.; Dos Santos, A. F.; Nepachalovich, P.; Pedrera, L.; Zilka, O.; Inague, A.; Klein, C.; Aroua, N.; Kaushal, K. et al.; Kast, B.; Lorenz, S. M.; Kunz, V.; Nehring, H.; Xavier da Silva, T. N.; Chen, Z.; Atici, S.; Doll, S. G.; Schaefer, E. L.; Ekpo, I.; Schmitz, W.; Horling, A.; Imming, P.; Miyamoto, S.; Wehman, A. M.; Genaro-Mattos, T. C.; Mirnics, K.; Kumar, L.; Klein-Seetharaman, J.; Meierjohann, S.; Weigand, I.; Kroiss, M.; Bornkamm, G. W.; Gomes, F.; Netto, L. E. S.; Sathian, M. B.; Konrad, D. B.; Covey, D. F.; Michalke, B.; Bommert, K.; Bargou, R. C.; Garcia Saez, A. J.; Pratt, D. A.; Fedorova, M.; Trumpp, A.; Conrad, M.; Friedmann Angeli, J. P.: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626, pp. 401 - 410 (2024)

King, L. E.; Hohorst, L.; García-Sáez, A. J.: Expanding roles of BCL-2 proteins in apoptosis execution and beyond. Journal of Cell Science 136 (22), jcs260790 (2023)

Czabotar, P. E.; Garcia-Saez, A. J.: Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nature Reviews Molecular Cell Biology 24 (10), pp. 732 - 748 (2023)

Pedrera, L.; Ros, U.; García-Sáez, A. J.: Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcium 114, 102778 (2023)

Rieger, J.; Fitz, M.; Fischer, S. M.; Wallmeroth, N.; Flores-Romero, H.; Fischer, N. M.; Brand, L. H.; García-Sáez, A. J.; Berendzen, K. W.; Mira-Rodado, V.: Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. Genes 14 (8), 1638 (2023)