Publications of Seah Ling Kuan

Gao, B.; Schäfers, C.; Kuan, S. L.; Weil, T.: A Supramolecular, Triple Negative Breast Cancer‐Targeting Avidin‐Photosensitizer. Macromolecular Bioscience 25 (6), 2400610 (2025)

Lantzberg, B.; Zeyn, Y.; Forster, R.; Lin, J.; Schauenburg, D.; Hieber, C.; Nuhn, L.; Zhou, T.; Silva, M. J.S.A.; Koynov, K. et al.; Jiang, H.-L.; Kuan, S. L.; Bros, M.; Opatz, T.; Weil, T.: Glycogen-inspired trimannosylated serum albumin nanocarriers for targeted delivery of toll-like receptor 7/8 agonists to immune cells and liver. Journal of Controlled Release 382, 113705 (2025)

Xu, L.; Silva, M. J.S.A.; Coelho, J. A. S.; Borho, J.; Stadler, N.; Barth, H.; Kuan, S. L.; Weil, T.: Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium. Nature Communications 16 (1), 5278 (2025)

Freisem, D.; Rodriguez-Alfonso, A. A.; Lawrenz, J.; Zhou, Z.; Monecke, T.; Preising, N.; Endres, S.; Wiese, S.; Ständker, L.; Kuan, S. L. et al.; Thal, D. R.; Weil, T.; Niessing, D.; Barth, H.; Kirchhoff, F.; Harms, M.; Münch, J.; Sparrer, K. M. J.: A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1. Cellular and Molecular Life Sciences 81, 409 (2024)

Yu, J.; Marchesi D'Alvise, T.; Harley, I.; Krysztofik, A.; Lieberwirth, I.; Pula, P.; Majewski, P. W.; Graczykowski, B.; Hunger, J.; Landfester, K. et al.; Kuan, S. L.; Shi, R.; Synatschke, C. V.; Weil, T.: Ion and Molecular Sieving With Ultrathin Polydopamine Nanomembranes. Advanced Materials 36 (29), 2401137 (2024)

Schauenburg, D.; Gao, B.; Rochet, L. N. C.; Schüler, D.; Coelho, J. A. S.; Ng, D. Y. W.; Chudasama, V.; Kuan, S. L.; Weil, T.: Macrocyclic Dual‐Locked "Turn‐On" Drug for Selective and Traceless Release in Cancer Cells. Angewandte Chemie International Edition 63 (18), e202314143 (2024)

Schauenburg, D.; Zech, F.; Heck, A. J.; von Maltitz, P.; Harms, M.; Führer, S.; Alleva, N.; Münch, J.; Kuan, S. L.; Kirchhoff, F. et al.; Weil, T.: Peptide Bispecifics Inhibiting HIV-1 Infection by an Orthogonal Chemical and Supramolecular Strategy. Bioconjugate Chemistry 34 (9), pp. 1645 - 1652 (2023)

Fuchs, N.; Meta, M.; Lantzberg, B.; Bros, M.; Kuan, S. L.; Weil, T.; Schirmeister, T.: Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible alpha-Fluorovinylsulfones and alpha-Sulfonates as Potential Immunomodulators in Cancer. ChemMedChem 18 (15), e202300160 (2023)

Rodríguez-Alfonso, A.; Heck, A.; Ruiz-Blanco, Y. B.; Gilg, A.; Ständker, L.; Kuan, S. L.; Weil, T.; Sanchez-Garcia, E.; Wiese, S.; Münch, J. et al.; Harms, M.: Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability. International Journal of Molecular Sciences 23 (23), 15029 (2022)

Raabe, M.; Heck, A.; Führer, S.; Schauenburg, D.; Pieszka, M.; Wang, T.; Zegota, M. M.; Nuhn, L.; Ng, D. Y. W.; Kuan, S. L. et al.; Weil, T.: Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates. Macromolecular Bioscience 22 (2), 2100299 (2022)

Zegota, M. M.; Müller, M.; Lantzberg, B.; Kizilsavas, G.; Coelho, J. A. S.; Moscariello, P.; Martínez Negro, M.; Morsbach, S.; Gois, P. M. P.; Wagner, M. et al.; Ng, D. Y. W.; Kuan, S. L.; Weil, T.: Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments. Journal of the American Chemical Society 143 (41), pp. 17047 - 17058 (2021)

Xu, L.; Silva, M. S. J. S. A.; Góis, P.; Kuan, S. L.; Weil, T.: Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents. Chemical Science 12 (40), pp. 13321 - 13330 (2021)

Vegi, N. M.; Chakrabortty, S.; Zegota, M. M.; Kuan, S. L.; Stumper, A.; Rawat, V. P. S.; Sieste, S.; Buske, C.; Rau, S.; Weil, T. et al.; Feuring-Buske, M.: Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis. Scientific Reports 10 (1), 371 (2020)

Xu, D.; Heck, A.; Kuan, S. L.; Weil, T.; Wegner, S.: Precise tetrafunctional streptavidin bioconjugates towards multifaceted drug delivery systems. Chemical Communications 56 (68), pp. 9858 - 9861 (2020)

Xu, L.; Raabe, M.; Zegota, M. M.; Nogueira, J. C. F.; Chudasama, V.; Kuan, S. L.; Weil, T.: Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation. Organic & Biomolecular Chemistry 18 (6), pp. 1140 - 1147 (2020)

Heck, A.; Ostertag, T.; Schnell, L.; Fischer, S.; Agrawalla, B. K.; Winterwerber, P.; Wirsching, E.; Fauler, M.; Frick, M.; Kuan, S. L. et al.; Weil, T.; Barth, H.: Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions. Advanced Healthcare Materials 8 (17), 1900665 (2019)

Wu, Y.; Li, L.; Frank, L.; Wagner, J.; Andreozzi, P.; Hammer, B.; D’Alicarnasso, M.; Pelliccia, M.; Liu, W.; Chakrabortty, S. et al.; Krol, S.; Simon, J.; Landfester, K.; Kuan, S. L.; Stellacci, F.; Müllen, K.; Kreppel, F.; Weil, T.: Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution. ACS Nano 13 (8), pp. 8749 - 8759 (2019)

Agrawalla, B. K.; Wang, T.; Riegger, A.; Domogalla, M. P.; Steinbrink, K.; Dörfler, T.; Chen, X.; Boldt, F.; Lamla, M.; Michaelis, J. et al.; Kuan, S. L.; Weil, T.: Chemoselective Dual Labeling of Native and Recombinant Proteins. Bioconjugate Chemistry 29 (1), pp. 29 - 34 (2018)

Kuan, S. L.; Fischer, S.; Hafner, S.; Wang, T.; Syrovets, T.; Liu, W.; Tokura, Y.; Ng, D. Y. W.; Riegger, A.; Förtsch, C. et al.; Jäger, D.; Barth, T. F. E.; Simmet, T.; Barth, H.; Weil, T.: Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins. Advanced Science 5 (8), 1701036 (2018)

Morsbach, S.; Gonella, G.; Mailänder, V.; Wegner, S.; Wu, S.; Weidner, T.; Berger, R.; Koynov, K.; Vollmer, D.; Encinas, N. et al.; Kuan, S. L.; Bereau, T.; Kremer, K.; Weil, T.; Bonn, M.; Butt, H.-J.; Landfester, K.: Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions. Angewandte Chemie International Edition 57 (39), pp. 12626 - 12648 (2018)