Targeting Nanocarriers to specific cells inside the human body

Proteins on nanocarriers: from the stealth effect to targeting in vivo (Project SFB1066 in B11 "Nanodimensional polymer therapeutics for tumor therapy" by the German Research Foundation )

Project: PD Dr. V. Mailänder , together with Dr. I. Lieberwirth and Dr. K. Koynov

This is a collaborative project in the framework of the SFB1066 (B11) which is performed between the group of Prof. Weil at the MPIP, Prof. Tenzer from the Institute of Immunology at the University Clinic of the Johannes Gutenberg University Mainz and the group of Prof. Mailänder. Based on the importance of the protein corona for cellular uptake and intracellular trafficking, which has been observed for nanoparticle systems, this project deals with three topics: (1) the further analysis of coronary formation and its effects in vivo, (2) the study of the possibility through pre-formation of the protein corona to modify the biodistribution and (3) the chemical attachment of key proteins such as clusterin to achieve a "stealth-like" behavior. We therefore join forces between the chemical modifications of antibodies, proteomics and pre-clinical evaluations.

For more info see the Homepage of the SFB1066 "Nanodimensional polymer therapeutics for tumor therapy"