Cell-Instructive Materials

Welcome to the homepage of the Gačanin Peretti-Schmucker Research Group !    
Cell-instructive Materials 

The team is comprised of interdisciplinary researchers, including biochemists, chemists, and material scientists. We are part of the Department of Synthesis of Macromolecules at the Max Planck Institute for Polymer Research in Mainz, Germany. 

We develop molecularly programmable and cell-instructive soft materials: Our research aims to establish a unified framework in which hierarchical molecular design principles govern structural order and emergent mechanical behavior across multiple length scales - from nanometre-scale structure formation to bulk hydrogel mechanics and applications. By programming this information directly into the sequence, we create materials that mimic the structural sophistication of biological systems while enabling synthetic tunability and robustness.

Central to this vision is the ability to engineer peptide and DNA sequences that organize through predictable supramolecular interactions, directional motifs, and cooperative hydrophobic/hydrophilic patterning.
 
These advances pave the way for peptide-based soft materials that couple structural precision with adaptability and have the potential to transform biofabrication processes and to create far-reaching opportunities in personal care, regenerative medicine, and other fields.

Selected Publications

Journal Article

1. Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties 
von Maltitz, P.; van Hilten, N.; Weil, T.; Thummaraj, T.; Methorst, J.; Aschmann, D.; Kros, A.; Read, C.; Gačanin, J.; Risselada, H. J. et al.:  Advanced Science, 2026, 13 (16), e13911 
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2. Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning.  Kaygisiz, K.; Ender, A. M.; Gačanin, J.; Kaczmarek, L. A.; Koutsouras, D. A.; Nalakath, A. N.; Winterwerber, P.; Mayer, F. J.; Räder, H. J.; Marszalek, T. et al.  Macromolecular Bioscience, 2023, 23, 2, 2200294  
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3. Biomedical Applications of DNA-Based Hydrogels
Gačanin, J., Synatschke, C. V., Weil, T.
Adv. Funct. Mater. 2020, 30, 1906253.
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4. Autonomous Ultrafast Self‐Healing Hydrogels by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices
Gačanin, J.; Hedrich, J., Sieste, S., Glaßer, G., Lieberwirth, I., Schilling, C., Fischer, S., Barth, H., Knöll, B., Synatschke, C. V., Weil, T.
Adv. Mater. 2019, 31, 1805044
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5. Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein–DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity
Gačanin, J.#, Kovtun, A.#, Fischer, S., Schwager, V., Quambusch, J., Kuan, S. L., Liu, W., Boldt, F., Li, C., Yang, Z., Liu, D., Wu, Y., Weil, T., Barth, H., Ignatius, A.
Adv. Healthcare Mater. 2017, 6, 1700392
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Review Article 

6. Biomedical Applications of DNA-Based Hydrogels
Gačanin, J.
, Synatschke, C. V., & Weil, T.. Advanced Functional Materials, 2020, 30, 4
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Patent applications

7. Hybrid Polymer Comprising a Polysaccharide Polymer and Peptide Chains.
Clariant Produkte Deutschland GmbH, Max Planck Society
Gačanin, J., Kayser, C., Lukowicz, L., Petrozziello, L., Synatschke, C., Wiechmann, L.,  Weil, T., MI 0903-6627 (2024)
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Research Highlights and News

2026

April, 17th
Jasmina’s talk “Designing Supramolecular Interactions: From Self-Assembly Towards 3D Soft Materials, Cell-Instruction and 3D Bioprinting” got accepted - see you at MSE 2026 in Darmstadt!

March, 18th 

HEAL-X BIOINK project meeting hosted by Gačanin group @MPI-P

February
Our manuscript “DNA-Liposome Hybrids Enable Energy Transfer Across Membrane Interfaces”,  with J. Bösking, R. Jacobi, N. Alleva, R. Nau, J. Gačanin, L. González, T. Weil, A. Pannwitz (CataLight B08) goes online on chemrxiv 

We welcome our project partners from Clariant @MPI-P for the interrim project meeting EcoRheo NxG

January 
Jasmina awarded Peretti–Schmucker Fellowship for research on skin biomaterials: Peretti-Schmucker Group to develop eco-friendly and self-healing soft material systems for dermatological care

Our manuscript “Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties” from our collaboration with P. v. Maltitz, N. v. Hilten, T. Weil, T. Thummaraj, J. Methorst, D. Aschmann, A. Kros, C. Read, J. Gačanin, H. Jelger Risselada, J. Münch is published in Advanced Science and available online now MPG.PuRe
 

2025 

Dezember 
Additional funding for the HEAL-X BIOINK (BMFTR) project - Digitalization of research data according to FAIR principles

September-October 
Cooperation via Rheinland-Pfalz & Scotland X Life Sciences fund - we welcome Toby Humphrey at MPI-P for a research stay and Baran visits Edinburgh.

Time to present our research abroad - Jasmina presents at ESB2025 in Torino, Italy. 

Jasmina also presents (online) as invited speaker at the Workshop on Regenerative Medicine & 3D Bioprinting, Bridging Placental Tissue Innovation with Translational Research in Belgade, Serbia. 

May 
HEAL-X BIOINK project meeting in Darmstadt @TUDa

April 
New project “Eco-Rheo NxG” as close and direct collaboration with Clariant confirmed

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