Cell-Instructive Materials

Welcome to the homepage of the Cell-Instructive Materials Group! 

The team is comprised of interdisciplinary researchers, including biochemists, chemists, and material scientists. We are part of the Department of Synthesis of Macromolecules at the Max Planck Institute for Polymer Research in Mainz, Germany. 

We develop cell-instructive soft materials: Our research focuses on multifunctional hybrid hydrogels for medicinal applications such as tissue engineering and drug delivery employing various biomolecules such as proteins, peptides, and DNA. Such soft materials that instruct cellular functions to e.g., restore damaged tissue while allowing minimally invasive application and therapeutic options are in high demand in regenerative medicine.

Inspired by the complex interplay of molecules in Nature, we explore the combination of the stability of covalent bonds with the dynamic behavior introduced by supramolecular chemistry and develop cell-instructive materials as active matrices featuring interactivity, responsiveness, and adaptability.

Selected Publications


1. Biomedical Applications of DNA-Based Hydrogels
Gačanin, J., Synatschke, C. V., Weil, T.
Adv. Funct. Mater. 2020, 30, 1906253.
Source
DOI

2. Autonomous Ultrafast Self‐Healing Hydrogels by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices
Gačanin, J., Hedrich, J., Sieste, S., Glaßer, G., Lieberwirth, I., Schilling, C., Fischer, S., Barth, H., Knöll, B., Synatschke, C. V., Weil, T.
Adv. Mater. 2019, 31, 1805044
Source
DOI

3. Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein–DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity
Gačanin, J.#, Kovtun, A.#, Fischer, S., Schwager, V., Quambusch, J., Kuan, S. L., Liu, W., Boldt, F., Li, C., Yang, Z., Liu, D., Wu, Y., Weil, T., Barth, H., Ignatius, A.
Adv. Healthcare Mater. 2017, 6, 1700392
Source
DOI

4. Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes
Marco Hebel, Andreas Riegger, Maksymilian M. Zegota, Gönül Kizilsavas, Jasmina Gačanin, Michaela Pieszka, Thorsten Lückerath, Jaime A. S. Coelho, Manfred Wagner, Pedro M. P. Gois, David Y. W. Ng, and Tanja Weil
Journal of the American Chemical Society 2019, 141 (36), 14026-14031
Source
DOI

5. Orthogonally Stimulated Assembly/Disassembly of Depsipeptides by Rational Chemical Design
M. Pieszka, A. M. Sobota, J. Gačanin, T. Weil, D. Y. W. Ng
ChemBioChem 2019, 20, 1376

Research Highlights and News

May 7, 2025

HEAL-X BIOINK project meeting in Darmstadt @TUDa

April 2025

New project “Eco-Rheo NxG” as close and direct collaboration with Clariant
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